Beta-Adrenergic Receptor Polymorphisms and Cardiac Graft Function in Potential Organ Donors
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چکیده
منابع مشابه
Adrenergic receptor polymorphisms and cardiac function (and dysfunction): a failure to communicate?
For a number of cardiovascular diseases, it has been proposed that both the susceptibility to disease and the interindividual variability in response to treatment relates in part to genetic polymorphisms, particularly those polymorphisms for neurotransmitter and drug receptors. Perhaps the most intensively studied family of receptors are the G-protein–coupled receptors, of which the b-adrenergi...
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Continuous exposure of cells to hormonal agonists often causes a rapid waning of the stimulated response. This desensitization effect has been extensively studied in the beta-adrenergic receptor system, and attributed largely to the rapid phosphorylation of the receptor by two kinases. Over a similar time frame (seconds to minutes), agonists also trigger a selective loss in the capacity of rece...
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Aims: Polymorphisms of the β-adrenergic receptor, the frequency of which may differ in ethnic groups, alters β-receptor function. The aim of this study was to elucidate the frequency of β1 and β2-adrenergic receptor polymorphisms in healthy Greeks and to compare with those of Caucasian European (Euro) and African American (AA) origin. Methods: Ninetynine individuals with a median age of 63 with...
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INTRODUCTION Congestive heart failure (CHF) is a major public health problem. Nearly 5 million Americans are afflicted with CHF and about 550,000 new cases are diagnosed each year (1). CHF is a pathophysiological condition in which the heart is unable to pump enough blood to meet the metabolic needs of the body. It is the endpoint for several cardiovascular diseases including coronary artery di...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2012
ISSN: 1600-6135
DOI: 10.1111/j.1600-6143.2012.04266.x